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Effect of cardiac catheterization on renal function.

B D Nunez1, M Allon

  • 1Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.

Clinical Nephrology
|December 1, 1990
PubMed
Summary
This summary is machine-generated.

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This study found a low risk of kidney damage from radiocontrast agents in patients undergoing cardiac catheterization. Sensitive tests showed no significant change in renal function, indicating safety for low-risk individuals.

Area of Science:

  • Nephrology
  • Cardiology
  • Radiology

Background:

  • Radiocontrast agents are frequently used in cardiac catheterization.
  • Nephrotoxicity is a potential complication, particularly in at-risk patients.
  • Assessing renal function changes requires sensitive methodologies.

Purpose of the Study:

  • To investigate the incidence of radiocontrast-induced nephrotoxicity.
  • To evaluate changes in renal function after cardiac catheterization using sensitive methods.
  • To identify risk factors for contrast-induced nephrotoxicity.

Main Methods:

  • Utilized sensitive acute renal clearance methodology.
  • Measured creatinine clearance before and after cardiac catheterization in 23 low-risk patients.

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  • Calculated creatinine clearance from four consecutive 30-minute renal clearance periods.

    • Main Results:

    • No significant change in creatinine clearance was observed post-procedure (101.5 +/- 6.4 ml/min pre vs. 111.6 +/- 7.4 ml/min post).
    • Only one patient (4.3%) experienced a decrease in creatinine clearance exceeding 25%.
    • Patient age, diabetes, and contrast volume were not identified as adverse risk factors.

    Conclusions:

    • Elective cardiac catheterization poses a low risk of nephrotoxicity in low-risk patients.
    • Sensitive measures of glomerular filtration rate confirm minimal impact on renal function.
    • Current protocols appear safe for this patient population regarding contrast-induced kidney injury.