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Updated: Jun 9, 2026
In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
Published on: May 11, 2021
[The expression of CEACAM-1 and CXCL-14 in infantile hemangioma]
Guang-Qi Xu1, Ren-Rong Lü, Ran Huo
1Department of Aesthetic Plastic and Burn Surgery Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Objective:
To examine the expression of CEACAM-land CXCL-14 in the different stages of infantile hemangioma and to explore the role of CEACAM-1 and CXCL-14 in the occurrence and development of infantile hemangioma.
Methods:
The expression of CEACAM-1 and CXCL-14 was detected by immunohistochemical technique and Western Blot in cases of proliferating hemangiomas, involuting hemangiomas, involuted hemangiomas. The mean optical density was measured by image analysis system.
Results:
The expression of CEACAM-1 in early stage of proliferating hemangiomas was weak or negative, while it was strong in involuting hemangiomas and positive in the involuted stage. The differences between different stages had a statistically significance (P < 0.05). The expression of CXCL-14 was weak or negative in stage of proliferating hemangiomas, positive in involuting hemangiomas and strong in the involuted stage. The differences between different stages had a statistically significance (P < 0.05).
Conclusions:
CEACAM-1 and CXCL-14 are involved in the occurrence and development of infantile hemangioma.
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