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Related Experiment Video

Updated: Jun 9, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
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Hyperviscosity syndrome associated with systemic plasmacytosis.

S Noda1, Y Tsunemi, Y Ichimura

  • 1Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan. m31071@gmail.com

Clinical and Experimental Dermatology
|August 27, 2010
PubMed
Summary

Systemic plasmacytosis can cause hyperviscosity-related retinopathy, a complication previously undescribed. Early funduscopic examination and treatment of this condition can reverse retinal changes.

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Area of Science:

  • Internal Medicine
  • Ophthalmology
  • Hematology

Background:

  • Systemic plasmacytosis involves plasma cell proliferation in multiple organs and polyclonal hypergammaglobulinaemia.
  • Hyperviscosity-related retinopathy has not been previously documented in association with systemic plasmacytosis.

Observation:

  • A 49-year-old Japanese woman with systemic plasmacytosis presented with fever, skin plaques, hypergammaglobulinaemia, renal failure, and bilateral retinal hemorrhage.
  • The patient exhibited symptoms consistent with hyperviscosity syndrome.

Findings:

  • Reduction of immunoglobulin levels through oral steroid therapy led to the reversal of retinopathy.
  • This suggests a direct link between hypergammaglobulinaemia and the observed retinal complications.

Implications:

  • Funduscopic examination is crucial for patients with systemic plasmacytosis and marked hypergammaglobulinaemia to detect early, asymptomatic retinal changes.
  • Prompt diagnosis and management of the underlying disease can effectively treat hyperviscosity-related retinopathy.