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Related Experiment Video

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Static Strength Training Method for Type 2 Diabetic Mice

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A new simple method for assessing sudomotor function: relevance in type 2 diabetes.

H Mayaudon¹, P-O Miloche, B Bauduceau

¹Service d'endocrinologie, hôpital d'instruction-des-armées-Bégin, 69 avenue de Paris, Saint-Mandé, France.

Diabetes & Metabolism

|August 27, 2010

Summary

EZSCAN effectively assesses sudomotor dysfunction in diabetic patients. This electrochemical skin conductance (ESC) test is sensitive, specific, and reproducible, offering a quick alternative for diagnosing autonomic neuropathy.

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Quantitative Autonomic Testing

Quantitative Autonomic Testing

Published on: July 19, 2011

Area of Science:

Clinical Neuroscience
Diabetology
Biomedical Engineering

Background:

Diabetic autonomic neuropathy often involves sudomotor dysfunction.
Current sudomotor function tests are time-consuming for clinical practice.
Electrochemical skin conductance (ESC) offers a novel approach.

Purpose of the Study:

To evaluate the sensitivity, specificity, and reproducibility of the EZSCAN device.
To compare ESC measurements in type 2 diabetic patients versus control subjects.
To establish EZSCAN as a diagnostic tool for diabetic sudomotor dysfunction.

Main Methods:

133 type 2 diabetic patients and 41 controls underwent ESC testing using EZSCAN.
Hands and feet were placed on electrodes; a low direct current was applied for 2 minutes.
Data analyzed using ROC curve modeling and Bland-Altman analysis for accuracy and reproducibility.

Main Results:

Diabetic patients showed significantly reduced ESC in hands (53±16μSi) and feet (67±14μSi) compared to controls (P<0.0001).
EZSCAN achieved 75% sensitivity and 100% specificity, with an AUC of 0.88.
Reproducibility showed coefficients of variation of 15% for hands and 7% for feet.

Conclusions:

EZSCAN demonstrates good sensitivity, specificity, and reproducibility for assessing sudomotor dysfunction.
The rapid, non-invasive EZSCAN test is a feasible alternative for diabetic autonomic neuropathy screening.
This technology requires minimal patient preparation and no specialized training.