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A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
2Struc: the secondary structure server
D P Klose1, B A Wallace, Robert W Janes
1School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK.
Bioinformatics (Oxford, England)
|August 27, 2010
Summary
2Struc provides access to eight secondary structure assignment methods for protein analysis. This server allows comparisons between methods and structural features within protein collections.
Area of Science:
- Structural Biology
- Bioinformatics
Background:
- The assignment of protein secondary structure from 3D coordinates is crucial in structural biology.
- While defined secondary structure methods are standard, alternative approaches exist.
Purpose of the Study:
- To provide a unified platform for accessing and comparing multiple protein secondary structure assignment methods.
- To facilitate the analysis of secondary structure content within single proteins and across collections of structures.
Main Methods:
- Development of '2Struc: The Secondary Structure Server' integrating eight distinct assignment algorithms.
- Implementation of a 'Compare-the-Protein' tool for cross-method and cross-structure comparisons.
Main Results:
- 2Struc offers a single point of access to diverse secondary structure assignment tools.
- The server enables detailed analysis and comparison of secondary structure features.
Conclusions:
- 2Struc enhances the comparative analysis of protein secondary structures.
- The server aids researchers in evaluating different assignment methods and their outputs.
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