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Acantholytic pilomatricoma.

H Nakayama¹, M Mihara, S Shimao

¹Department of Dermatology, Tottori University School of Medicine, Yonago, Japan.

Dermatologica

|January 1, 1990

Summary

This case report details an acantholytic variant of pilomatricoma, a rare skin tumor. The findings describe a unique presentation of this benign neoplasm in an 11-year-old girl.

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Area of Science:

Dermatopathology
Pediatric Oncology

Background:

Pilomatricoma is a benign skin tumor originating from hair matrix cells.
It typically presents as a firm, subcutaneous nodule, most commonly on the head and neck of children.
The classic histopathological features include nests of basaloid cells and 'shadow cells'.

Observation:

An 11-year-old girl presented with a painful, pink-red scalp tumor.
The lesion demonstrated multiple dermal nests composed of peripheral basophilic cells and central shadow/eosinophilic cells.
Epithelial cysts with acantholytic changes in the cyst wall were noted within the tumor nests.

Findings:

The histopathological features suggest an acantholytic variant of pilomatricoma.
This variant is characterized by the presence of acantholysis within the epithelial cysts.
This represents a potentially novel presentation of a pilomatricoma.

Implications:

Recognizing this acantholytic variant is crucial for accurate diagnosis and appropriate management of pilomatricoma.
This finding expands the spectrum of histopathological presentations of pilomatricoma.
Further research may elucidate the specific mechanisms underlying the acantholytic changes in this tumor type.

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