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Related Experiment Video

Updated: Jun 9, 2026

Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry

Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry

Published on: August 7, 2012

Comparative human salivary and plasma proteomes.

J A Loo¹, W Yan, P Ramachandran

¹Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, USA.

Journal of Dental Research

|August 27, 2010

Summary

This summary is machine-generated.

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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Human saliva contains a vast proteome, with significant overlap in protein functions and disease markers compared to blood plasma. Saliva offers a promising, non-invasive fluid for discovering novel disease biomarkers.

Area of Science:

Proteomics
Biochemistry
Biomarker Discovery

Background:

Human saliva and plasma proteomes are crucial for understanding physiological and pathological states.
Previous research has cataloged numerous proteins in both bodily fluids, but direct proteomic comparisons are limited.

Purpose of the Study:

To compare the protein composition of human whole saliva and plasma.
To assess the overlap in identified proteins and their functional distributions.
To evaluate the potential of saliva as a source for disease biomarker discovery.

Main Methods:

Compilation of a comprehensive catalog of 2290 proteins identified in human whole saliva.
Comparison of the salivary proteome with a catalog of 2698 proteins identified in human plasma.

Related Experiment Videos

Last Updated: Jun 9, 2026

Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry

Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry

Published on: August 7, 2012

Analysis of Gene Ontological categories (molecular function, biological processes, cellular components) for both proteomes.

Main Results:

Approximately 27% of identified whole-saliva proteins are also present in plasma.
Despite low direct overlap, significant similarities were observed in the distribution of proteins across Gene Ontological categories.
Nearly 40% of candidate disease markers (e.g., for cancer, cardiovascular disease, stroke) are detectable in whole saliva.

Conclusions:

Saliva shares functional protein profiles with plasma, suggesting its utility in diagnostics.
Whole saliva is a viable and accessible biofluid for identifying novel protein markers of systemic diseases.
Further research into salivary diagnostics can lead to non-invasive early disease detection.