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Apolipoprotein E gene polymorphism and total serum cholesterol level in Iranian population
J T Bazzaz1, M Nazari, H Nazem
1Endocrinology and Metabolism Research Centre, Tehran University of Medical Sciences, Tehran, Iran.
Journal of Postgraduate Medicine
|August 27, 2010
Summary
The Apolipoprotein E (APOE) gene
Area of Science:
- Genetics
- Biochemistry
- Cardiovascular Disease Risk Factors
Background:
- Apolipoprotein E (APOE) regulates blood lipid levels.
- APOE gene variants (E2, E3, E4) are linked to obesity, BMI, and plasma lipids in children.
- This study investigates APOE's role in an Iranian cohort.
Purpose of the Study:
- To examine the association between APOE genetic variants and Body Mass Index (BMI).
- To assess the relationship between APOE genetic variants and lipid profiles.
- To investigate cardiovascular disease risk factors in an Iranian population.
Main Methods:
- 320 subjects recruited from a MONICA study in Tehran.
- Genotyping for APOE variants using PCR-RFLP.
- Analysis of triglyceride and total serum cholesterol levels.
Main Results:
- APOE allele E2 frequency was higher in individuals with total cholesterol <200 mg/dl.
- Genotypes E2/E3 and E2/E4 were more frequent in subjects with normal cholesterol levels.
- A significant association was found between APOE E2 and lower total cholesterol.
Conclusions:
- APOE allele E2 is associated with lower total cholesterol levels, consistent with prior research.
- Specific APOE genotypes (E2/E3, E2/E4) correlate with normal cholesterol levels.
- Further research with larger populations and detailed lipid profiles (LDL, HDL) is recommended.
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