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Intracranial meningiomas of atypical (WHO grade II) histology

Leland Rogers1, Mark Gilbert, Michael A Vogelbaum

  • 1GammaWest Cancer Services, Salt Lake City, UT, USA. Leland@GammaWest.com

Journal of Neuro-Oncology
|August 27, 2010
PubMed

Insights

Atypical (WHO grade II) meningiomas are now more common due to updated criteria, posing a higher risk of recurrence and mortality. Further research is needed to standardize diagnosis and treatment for these intermediate-risk brain tumors.

Area of Science:

  • Neuro-oncology
  • Pathology
  • Neurosurgery

Background:

  • Atypical meningiomas (WHO grade II) represent an intermediate risk category.
  • Updated 2007 WHO diagnostic criteria increased their reported incidence from 5% to 20-35% of all meningiomas.
  • This shift necessitates standardized diagnostic and treatment protocols.

Purpose of the Study:

  • To discuss the definition, diagnosis, and treatment of atypical meningiomas.
  • To review current phase II cooperative clinical trials.
  • To highlight areas for future pre-clinical and clinical research.

Main Methods:

  • Review of diagnostic criteria and incidence data for WHO grade II meningiomas.
  • Analysis of recurrence and mortality rates.
  • Examination of current clinical trial landscape.

Main Results:

  • Atypical meningiomas show a significantly increased risk of recurrence and mortality compared to benign types.
  • The revised WHO classification has substantially increased the diagnosed incidence of grade II meningiomas.
  • Standardization of diagnostic criteria and inter-institutional comparisons are crucial.

Conclusions:

  • Atypical meningiomas require careful management due to their intermediate-risk profile.
  • Further research is essential to refine diagnostic accuracy and optimize treatment strategies.
  • Addressing the increased incidence and associated risks is a priority in neuro-oncology.

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