Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The lipoprotein lipase system: new understandings.

M H Tan

    Canadian Medical Association Journal
    |March 18, 1978
    PubMed
    Summary

    High triglyceride levels, a risk for atherosclerosis, are linked to reduced tissue triglyceride use. Studying specific lipoprotein lipase (LPL) from tissues is crucial for understanding hypertriglyceridemia mechanisms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Exogenous bone sialoprotein improves extraction socket healing in Ibsp knockout and wild-type mice.

    Bone·2024
    Same author

    [Exophytic teratoma-like parasitic fetus in the sacrococcygeal region of the fetus: report of a case].

    Zhonghua bing li xue za zhi = Chinese journal of pathology·2024
    Same author

    Bone Sialoprotein Is Critical for Alveolar Bone Healing in Mice.

    Journal of dental research·2022
    Same author

    The Bone Sialoprotein RGD Domain Modulates and Maintains Periodontal Development.

    Journal of dental research·2022
    Same author

    The eyes that saw the kidneys.

    The Medical journal of Malaysia·2022
    Same author

    Effects of Active Vitamin D or FGF23 Antibody on <i>Hyp</i> Mice Dentoalveolar Tissues.

    Journal of dental research·2021

    Area of Science:

    • Biochemistry
    • Metabolic Diseases
    • Lipid Metabolism

    Background:

    • Hypertriglyceridemia is a significant risk factor for premature atherosclerosis.
    • Tissue utilization of plasma triglycerides is impaired in hypertriglyceridemia.
    • Lipoprotein lipase (LPL) mediates triglyceride removal, and its activity is assessed via post-heparin plasma lipolytic activity (PHLA).

    Purpose of the Study:

    • To clarify the mechanisms of hypertriglyceridemia by investigating the role of LPL.
    • To address the interpretational challenges of total PHLA due to the presence of non-LPL enzymes.
    • To explore the heterogeneity of LPL and the significance of its tissue-specific forms and activators.

    Main Methods:

    • Utilizing assays for the LPL component of PHLA to resolve ambiguities in hypertriglyceridemia studies.
    • Investigating tissue-specific LPL "isoenzymes" under various metabolic conditions.
    • Characterizing the serum activator for LPL.

    Main Results:

    • LPL component assays have clarified previous equivocal findings in certain hypertriglyceridemic states.
    • Evidence suggests LPL is heterogeneous, with different extrahepatic tissue LPLs exhibiting distinct metabolic behaviors.
    • A patient with hypertriglyceridemia deficient in the LPL serum activator has been identified, highlighting its importance.

    Conclusions:

    • Understanding the LPL system requires studying specific tissue LPLs due to heterogeneity.
    • The LPL serum activator plays a critical role in lipid metabolism, as evidenced by deficiency-related hypertriglyceridemia.
    • Further research into tissue-specific LPL and its activators is essential for managing hypertriglyceridemia and preventing atherosclerosis.

    Related Experiment Videos