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Related Experiment Video

Updated: Jun 9, 2026

A Microfluidic Chip for ICPMS Sample Introduction

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

Ionspray microchip.

Jaroslav Pól¹, Tiina J Kauppila, Sami Franssila

¹Division of Pharmaceutical Chemistry, Faculty of Pharmacy, P.O. Box 56, FI-00014 University of Helsinki, Finland. jaroslav.pol@helsinki.fi

Rapid Communications in Mass Spectrometry : RCM

|August 27, 2010

Summary

A novel ionspray microchip, based on a nebulizer chip, efficiently ionizes compounds for analysis. This microchip demonstrates good performance in liquid chromatography/mass spectrometry (LC/MS) for peptide analysis.

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Last Updated: Jun 9, 2026

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Area of Science:

Analytical Chemistry
Microfluidics
Mass Spectrometry

Background:

Nebulizer microchips have been utilized in various ionization techniques.
Previous designs integrated glass and silicon plates with etched channels and heaters.

Purpose of the Study:

To introduce and characterize an ionspray microchip for enhanced ionization.
To investigate the operational parameters affecting ionspray microchip performance.

Main Methods:

Fabrication of a microchip by bonding glass and silicon plates.
Integration of a platinum heater and etched channels for liquid and gas inlets.
Application of high voltage to the silicon plate for ionspray ionization.

Main Results:

The microchip was successfully operated in ionspray mode.
Optimized parameters yielded efficient ionization of diverse compounds.
Good quantitative performance was achieved.

Conclusions:

The ionspray microchip offers efficient ionization for small and large molecules.
The microchip is feasible for liquid chromatography/mass spectrometry (LC/MS) applications.
Demonstrated utility in analyzing tryptic peptides of bovine serum albumin.