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Protein adsorption on biodegradable polyanhydride microparticles.

Brenda Carrillo-Conde1, Alicia Garza, James Anderegg

  • 1Department of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011, USA.

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Polyanhydride microparticles adsorb varying amounts of plasma proteins like albumin, immunoglobulin G, and fibrinogen. Protein adsorption correlates with polymer hydrophobicity, impacting drug release from delivery devices.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surface Science

Background:

  • Polyanhydride microparticles are utilized in parenteral drug delivery systems.
  • Understanding protein adsorption onto biomaterials is crucial for predicting in vivo performance and efficacy.
  • The surface properties of microparticles influence protein-material interactions.

Purpose of the Study:

  • To investigate the in vitro adsorption of plasma proteins onto polyanhydride microparticles.
  • To determine the influence of copolymer composition and protein type on adsorption.
  • To assess the impact of protein adsorption on drug release from microparticles.

Main Methods:

  • Synthesis of polyanhydride microparticles using sebacic acid (SA), 1,6-bis(p-carboxyphenoxy)hexane (CPH), and 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG).
  • In vitro adsorption studies using model proteins: bovine serum albumin (BSA), immunoglobulin G (IgG), and fibrinogen (Fg).
  • Surface analysis via X-Ray Photoelectron Spectroscopy (XPS) and gel electrophoresis (including 2D electrophoresis).
  • In vitro drug release studies using ovalbumin-encapsulated microparticles.

Main Results:

  • Protein adsorption varied significantly based on both the polyanhydride copolymer composition and the specific protein studied.
  • A direct correlation was observed between polymer hydrophobicity and the amount of protein adsorbed, with higher adsorption for fibrinogen (Fg) and immunoglobulin G (IgG).
  • Adsorption of fibrinogen (Fg) onto the microparticle surface reduced the in vitro release rate of encapsulated ovalbumin.

Conclusions:

  • The hydrophobicity of polyanhydride microparticles is a key determinant of plasma protein adsorption.
  • Protein adsorption patterns can modulate the drug release kinetics from microparticle-based delivery systems.
  • These findings provide valuable insights for optimizing the design of parenteral delivery devices to improve in vivo performance.