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Cefodizime, a new 2-aminothiazolyl cephalosporin: physicochemical properties, toxicology and structure-activity
A Bryskier1, T Procyk, M T Labro
1Centre de recherche Roussel-Uclaf, Romainville, France.
The Journal of Antimicrobial Chemotherapy
|November 1, 1990
Abstract:
Cefodizime is a 2-aminothiazolyl cephalosporin for parenteral use. Cefodizime has a bisubstituted thiothiazole moiety in position 3 of the cephem nucleus. The presence of this moiety does not alter the in-vitro antibacterial activity, or safety in animal studies, which are similar to those of cefotaxime, but results in an apparent long elimination half-life in rodents and dogs, and in novel immunological properties.