Squamous cell carcinoma in situ overlying dermatofibroma

Area of Science:

• Dermatopathology
• Oncology

Background:

• Dermatofibromas are common benign skin tumors.
• Previous reports noted benign epidermal changes or rare invasive basal cell carcinoma overlying dermatofibromas.

Observation:

• This case presents a dermatofibroma with an unusual overlying neoplastic change.

Findings:

• The study documents the first known case of a dermatofibroma associated with in situ squamous cell carcinoma.
• This highlights a rare but significant malignant transformation occurring in the epidermis above a dermatofibroma.

Implications:

• This finding broadens the differential diagnosis for epidermal changes overlying dermatofibromas.
• It underscores the importance of vigilant histopathological examination of dermatofibromas, especially those with atypical epidermal features.