Does beta 2 adrenergic agonism affect local anaesthetic efficacy?

It is theoretically possible that adrenaline might increase local anaesthetic efficacy by a specific beta 2 adrenergic agonistic mechanism by which nerve cell membranes are hyperpolarized. This study compares the anaesthetic efficacy of a local anaesthetic containing the beta 2 adrenergic agonist salbutamol to adrenaline-containing and plain local anaesthetic solutions following intradermal injections. The findings indicate that beta 2 adrenergic agonism did not affect local anaesthetic efficacy in the model employed.