[Comparison of the effectiveness of dental local anesthetics in guinea pig]

A large number of local anesthetics has been marketed for clinical use. The purpose of this study was to compare the effectiveness of nine local anesthetics used in dentistry. After subcutaneous injection of 0.1 ml of local anesthetic into the guinea pig's back, the onset and duration of action were determined by stimulating with an electric current. The onset of action of these local anesthetics occurred immediately. But the duration of action was statistically significant different (P less than 0.01, ANOVA and Duncan's New Multiple Range Test). The duration of action ranging from 7.0 to 73.2 minutes was divided into 5 groups as the following: 1. Benadryl and Xylocaine plane. 2. Xylocaine plane and Lidocaton. 3. Citanest and Octocaine. 4. Octocaine and Neo-lidocaton. 5. Neo-lidocaton, Xylestesin-F, Xylocaine c noradrenaline 1:50,000 and Xylocaine c adrenaline 1:80,000. The result of this study will be useful for the dentists to select the appropriate local anesthetics for their treatment.