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An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Current therapy of bladder cancer

W F Whitmore1

  • 1Urology Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.

Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association
|September 1, 1990
PubMed

Insights

Bladder cancer treatment varies by tumor type. Superficial cancers need intravesical therapies, while invasive cancers benefit from systemic chemotherapy, improving survival and bladder preservation.

Area of Science:

  • Oncology
  • Urology

Background:

  • Bladder cancer presents as a heterogeneous spectrum of neoplasms.
  • Treatment strategies differ based on tumor stage, with superficial tumors facing recurrence and muscle-infiltrating tumors risking metastasis.

Purpose of the Study:

  • To review current treatment modalities for bladder cancer.
  • To highlight advancements in systemic chemotherapy for advanced disease.
  • To emphasize the need for tailored therapy based on tumor heterogeneity.

Main Methods:

  • Review of existing literature on bladder cancer treatments.
  • Analysis of treatment outcomes for superficial and muscle-infiltrating bladder cancers.
  • Discussion of evolving systemic chemotherapy regimens and pilot studies.

Main Results:

  • Local control is achievable with appropriate treatment selection.
  • Intravesical therapies are effective for superficial neoplasms.
  • Systemic chemotherapy has led to significant advancements, including combination regimens with complete responses.

Conclusions:

  • Tumor heterogeneity necessitates precise characterization for optimal, individualized bladder cancer therapy.
  • Ongoing research focuses on improving survival and bladder preservation through combined treatment approaches.
  • A move towards more rational, less empirical treatment selection is crucial given expanding therapeutic options.

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