Related Experiment Video
Updated: Aug 18, 2026

Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface
Published on: November 2, 2011
The effect of multivalent cations on adhesion time for cellular adhesion to solid surfaces
1Department of Chemical Engineering, Tunghai University, Taichung, Taiwan, R.O.C.
Abstract:
The dynamic behavior of the adhesion of a charge-regulated cell to a solid surface of constant potential is investigated. In particular, the effect of the presence of multivalent cations in the suspension medium on adhesion time is discussed. By neglecting the effect of hydrodynamic retardation and assuming that the bulk liquid phase is stagnant, we show that the presence of multivalent cations has the effect of retarding cell adhesion. At a fixed level of ionic strength, the adhesion time increases with the increase of the concentration of multivalent cations in the suspension medium, and decreases with the increase in magnitude of the Hamaker constant. For a fixed concentration of cations, the adhesion time decreases with the increase of ionic strength. The effect of the magnitude of Hamaker constant on adhesion time is appreciable if both the ionic strength and the concentration of cations are high.
Related Concept Videos
Adhesion
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
Intracellular Signaling Affects Focal Adhesions
Some...
Adherens Junctions
Adherens Junctions are Dynamic
The endothelial cells...
Cell Adhesion Molecules - Types and Functions
CAM Families
The Integrin family of proteins is primarily involved in a...
Selectins
Immunoglobulin-like Cell Adhesion Molecules
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

