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Related Experiment Videos

Citrate haemodialysis.

L M Faber1, P M de Vries, P L Oe

  • 1Department of Internal Medicine, Free University Hospital, Amsterdam.

The Netherlands Journal of Medicine
|December 1, 1990
PubMed
Summary
This summary is machine-generated.

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Sodium citrate is a suitable anticoagulant for hemodialysis in high-risk bleeding patients. However, prolonged use may cause paresthesias due to metabolic alkalosis and low calcium, requiring dialysate adjustments.

Area of Science:

  • Nephrology
  • Hematology

Background:

  • Patients undergoing hemodialysis often require anticoagulation.
  • High-risk bleeding patients present challenges for standard anticoagulation methods like heparin.

Purpose of the Study:

  • To evaluate the efficacy and safety of sodium citrate as an anticoagulant in hemodialysis for patients at high risk of bleeding.
  • To compare citrate anticoagulation with heparin anticoagulation in prolonged hemodialysis sessions.

Main Methods:

  • Retrospective analysis of 15 high-risk bleeding patients undergoing hemodialysis with sodium citrate.
  • Comparison of the last month of heparin dialysis with the first month of citrate dialysis in six patients on prolonged treatment.

Main Results:

  • Sodium citrate proved suitable as an anticoagulant in this high-risk group.

Related Experiment Videos

  • Prolonged citrate dialysis led to paresthesias, likely linked to citrate-induced metabolic alkalosis and hypocalcemia.
  • Adjustments to dialysate composition (reduced acetate, calcium- and magnesium-free) are suggested to mitigate side effects.

    • Conclusions:

    • Sodium citrate is a viable anticoagulant option for hemodialysis in bleeding-risk patients.
    • Careful monitoring and dialysate modification are necessary to manage side effects during prolonged citrate anticoagulation.