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Coffee, caffeine and hemostasis: a review.

A A Bak1, D E Grobbee

  • 1Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam.

The Netherlands Journal of Medicine
|December 1, 1990
PubMed
Summary

Coffee consumption may increase thrombotic tendencies, impacting blood clotting. Further research, including randomized controlled trials, is needed to confirm coffee

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Area of Science:

  • Cardiovascular Science
  • Haemostasis Research
  • Nutritional Epidemiology

Background:

  • The relationship between coffee consumption and cardiovascular disease necessitates understanding its effects on haemostasis.
  • Existing evidence on coffee's impact on blood clotting is conflicting and inconclusive.
  • Haemostatic variables are crucial in assessing thrombotic tendencies and cardiovascular risk.

Purpose of the Study:

  • To review the current evidence on the effects of coffee and caffeine on haemostatic variables.
  • To evaluate the potential link between coffee consumption and an increased risk of thrombosis.
  • To identify gaps in the research and suggest future study directions.

Main Methods:

  • Systematic review of existing literature on coffee, caffeine, and haemostasis.
  • Analysis of studies examining fibrinogen levels and platelet activation markers (e.g., beta-thromboglobulin).
  • Assessment of the reliability and consistency of findings across different studies.

Main Results:

  • Available evidence suggests coffee consumption may unfavorably affect haemostasis, potentially enhancing thrombotic tendencies.
  • Findings on fibrinogen levels and in vivo platelet activation (beta-thromboglobulin) appear most reliable.
  • Conflicting data exists, highlighting the need for more robust research.

Conclusions:

  • Current evidence indicates a potential pro-thrombotic effect of coffee, but findings are not definitive.
  • More high-quality research, particularly randomized controlled trials in humans, is required.
  • Further investigation is needed to understand the clinical significance of coffee's impact on the haemostatic system at commonly consumed levels.

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