[Effect of alkalies on gastric acidity in patients with duodenal ulcer]

Acidity of the gastric juice was measured following single oral dose of fluid and powdered alkalizing agents. It was found that liquid form of such an agent (Alugastrin) in a dose of 30 mL effectively increases intragastric pH to 5.0-6.0 and maintains it at 3.0-4.0 for 60 to 90 minutes. This agent similarly neutralizes gastric content in patients with or without duodenal ulcer. Tablet forms of alkalizing agents (Gastrin and Wikalina) increase pH to 7.5 within 10 minutes and maintain it at 3.0-4.0 for 90 minutes whereas other brands (Alusal and Magnosil) slightly alkalize gastric content for 30 minutes. The studies indicate that preparations Alugastrin, Gastrin and Wikalina efficiently alkalize gastric juice for longer period of time than Maalox. Therefore, more frequent--every 1 to 1.5 hours--administration of alkalizing agents is recommended in order to increase intragastric pH in those diseases which require the elimination of hydrochloric acid.