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Related Experiment Videos

Chemical respiratory control in chronically hyperoxic cats.

S Lahiri1, A Mokashi, M Shirahata

  • 1Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia.

Respiration Physiology
|November 1, 1990
PubMed
Summary

Chronic normobaric hyperoxia in cats selectively impaired carotid chemosensory responses to hypoxia. This led to ventilatory depression despite preserved central chemoreflex pathways.

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Area of Science:

  • Respiratory Physiology
  • Neuroscience
  • Environmental Medicine

Background:

  • Normobaric hyperoxia (NH) involves breathing 100% oxygen at normal atmospheric pressure.
  • Chronic exposure to hyperoxia can alter physiological responses, particularly respiratory control.
  • Understanding these alterations is crucial for managing conditions involving altered oxygen levels.

Purpose of the Study:

  • To investigate the effects of chronic normobaric hyperoxia on the chemical control of respiration in cats.
  • To compare the respiratory responses to hypoxia and hypercapnia after hyperoxia exposure.
  • To determine the integrity of carotid chemosensory and central chemoreflex pathways post-hyperoxia.

Main Methods:

  • Cats were exposed to chronic normobaric hyperoxia (100% O2 for 60-67 hours).

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  • Respiratory responses (inspiratory time, tidal volume) to induced hypoxia and hypercapnia were measured.
  • Carotid chemosensory responses to pharmacological agents (nicotine, dopamine, cyanide) were assessed.

    • Main Results:

    • Hypoxia induced changes in inspiratory time and tidal volume, indicating impaired respiratory drive.
    • Responses to hypercapnia were subnormal, suggesting altered ventilatory control.
    • Carotid chemosensory responses to nicotine and dopamine were preserved, but cyanide failed to stimulate.
    • Central chemoreflex pathways appeared intact, but hypoxia caused ventilatory depression.

    Conclusions:

    • Chronic normobaric hyperoxia selectively attenuated carotid chemosensory and chemoreflex responses to hypoxia.
    • The central component of the chemoreflex was not impaired, but airway reflexes may have increased responsiveness.
    • Hypoxia-induced ventilatory depression in hyperoxia-exposed cats is linked to impaired carotid chemosensory input and potential central depressant effects.