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Detection of multiple invasion of erythrocytes by Plasmodium vivax
R N Prasad1, H Prasad, K J Virk
1Malaria Research Centre (ICMR), Shahjahanpur, India.
Abstract:
An attempt was made to detect multiple invasion of erythrocytes by Plasmodium vivax in district Shahjahanpur, India. Out of 33,027 P. vivax cases examined, 84 showed multiple invasion of erythrocytes. There were 14 cases who showed more than five rings in an erythrocyte. Maximum invasion of an erythrocyte was observed in a 50 year old male patient, a single erythrocyte was harbouring 12 rings. In 5 patients more than one schizonts were present in single erythrocyte. The number of merozoites per schizont varied from 2-28. In some of the cases erythrocytes were having more than one stage of the malarial parasite. Such variations are probably related to the P. vivax strain found in this area.
Insights
Multiple Plasmodium vivax parasite invasion of red blood cells was detected in India. Some erythrocytes contained over five rings, with one harboring twelve rings, suggesting unique local parasite strains.
Area of Science:
- Medical Parasitology
- Infectious Diseases
- Malariology
Background:
- Plasmodium vivax is a major cause of malaria globally.
- Erythrocyte invasion patterns can influence malaria pathogenesis and treatment.
- Understanding parasite behavior is crucial for malaria control.
Purpose of the Study:
- To investigate the occurrence and extent of multiple erythrocyte invasion by Plasmodium vivax.
- To characterize variations in parasite multiplication within single erythrocytes.
Main Methods:
- Microscopic examination of blood smears from Plasmodium vivax infected patients.
- Quantification of parasite rings and schizonts within individual erythrocytes.
- Analysis of parasite developmental stages within infected red blood cells.
Main Results:
- Out of 33,027 Plasmodium vivax cases, 84 exhibited multiple erythrocyte invasion.
- Fourteen cases showed more than five rings per erythrocyte; one erythrocyte contained 12 rings.
- Multiple schizonts were observed in 5 patients, with merozoite counts ranging from 2-28.
- Some erythrocytes contained multiple parasite developmental stages.
Conclusions:
- Multiple erythrocyte invasion by Plasmodium vivax occurs in Shahjahanpur, India.
- Observed variations in invasion and development may be linked to local Plasmodium vivax strains.
- Further research into these unique parasite strains is warranted.