Related Experiment Videos
[Response to histamine in the skin prick test in children]
Insights
Histamine skin reactivity in children showed no significant differences between sexes or allergic conditions. Peak reactions occurred at 5 minutes, declining by 15 minutes in allergy prick testing.
Area of Science:
- Pediatric Allergy
- Dermatology
- Immunology
Context:
- Assessing allergen skin reactivity is crucial for diagnosing allergic conditions in children.
- Histamine serves as a positive control in skin prick testing to validate skin responses.
Purpose:
- To investigate histamine skin reactivity in a pediatric population with diverse allergic symptoms.
- To determine if sex, allergic disorder type, or anatomical site influences histamine-induced skin reactions.
Summary:
- A study involving 183 children (4 months to 15 years) assessed skin reactivity to histamine via prick testing.
- No significant differences in histamine skin reactions were observed between males and females, across different allergic disorders (respiratory, pollen, skin), or on various arm locations.
- Repeated histamine applications did not alter reaction volume, with peak reactions typically occurring at 5 minutes and diminishing by 10-15 minutes.
Impact:
- Provides normative data on histamine skin reactivity in children, aiding in the interpretation of allergy testing.
- Highlights the consistency of histamine responses, reinforcing its utility as a control in pediatric allergy diagnostics.
- Contributes to understanding the physiological basis of immediate hypersensitivity reactions in pediatric dermatology.
Abstract:
Allergen skin reactivity to histamine assessed by Prick testing was studied in 183 children with different allergic symptoms, aged from 4 months to 15 years. No significant difference was noted in male children versus female in different parts of the arm (antecubital fossa of the left arm, wrist of both arms) and in different allergic disorders (respiratory, pollen and skin allergy). The volume of reaction was not significantly changed in repeated applications of histamine. The peak reaction to histamine appeared 5 minutes after the application of histamine in the majority of children; it gradually declined after 10 and 15 minutes.