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Cardiovascular effect of skimmianine in rats
J T Cheng1, S S Chang, I S Chen
1Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, Republic of China.
Archives Internationales De Pharmacodynamie Et De Therapie
|July 1, 1990
Abstract:
Skimmianine, a general component contained in the plants of Rutaceae, was found to have a selective inhibitory effect on the 5-hydroxytryptamine-induced vasopressor responses of rats. A similar inhibitory action was also observed in the isolated atria. Moreover, skimmianine produced a nonspecific blockade of the cardiovascular functions at higher concentration.