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Nonuniform distribution of normal pericardial fluid
W P Santamore1, M S Constantinescu, D Bogen
1Philadelphia Heart Institute, Presbyterian Medical Center, Pennsylvania.
Basic Research in Cardiology
|November 1, 1990
Summary
Canine pericardial fluid is thin, especially on ventricular walls, suggesting it acts as a lubricant. This fluid distribution may allow regional variations in pericardial pressure.
Area of Science:
- Cardiovascular Physiology
- Biomedical Engineering
Background:
- The function of pericardial fluid is debated, with suggestions it acts as a lubricant or pressure transmitter.
- Pericardial fluid dynamics are influenced by its thickness and distribution within the pericardial space.
Purpose of the Study:
- To measure pericardial fluid volume and assess its distribution in canines.
- To investigate the relationship between pericardial fluid thickness and its proposed functions.
Main Methods:
- Quantified pericardial fluid volume and calculated average thickness in canine subjects.
- Visualized pericardial fluid distribution using dye injection and video imaging in anesthetized dogs.
Main Results:
- Normal canine pericardium contains 0.25 ± 0.15 ml/kg of fluid, averaging 0.34 ± 0.27 mm in thickness.
- Dye distribution revealed significant nonuniformity, accumulating in grooves and sparse on free walls.
- Pericardial fluid thickness varies regionally, being thin over ventricular free walls and thicker in grooves.
Conclusions:
- Regional variations in pericardial fluid thickness support a dual role: lubrication on free walls and potential pressure transmission in grooves.
- Thin pericardial fluid on ventricular free walls suggests a primary lubricant function in these areas.