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Changes in mandible and femur proteoglycans. Physico-chemical properties after hydrocortisone treatment
J A Kofoed1, S M Fernández Lemos, O Barbato
1Faculty of Dentistry, University of Buenos Aires, Argentina.
Acta Odontologica Latinoamericana : AOL
|January 1, 1990
Abstract:
Male Wistar rats were injected with 5 mg/kg/day of hydrocortisone during 21 days. Femur and mandible proteoglycans (PG) were isolated and their physico-chemical properties were compared with bone PG from a control and a starved group. The PG molecular weight decreased as a result of the hydrocortisone treatment but to a lower degree than in starvation, whereas the PG density seemed to be more affected by corticosteroid injection. These results allow us to conclude that bone alterations found after glucosteroid treatment may be due--at least partially--to changes in the PG physico-chemical properties of that tissue.