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[cis-diamminedichloroplatinum cochlear toxicity].

¹Second Affiliated Hospital of Tianjin Medical College.

Zhonghua Er Bi Yan Hou Ke Za Zhi

|August 1, 1990

Summary

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DDP ototoxicity causes dose-dependent cochlear damage, affecting hearing thresholds and hair cells. This study reveals DDP

Area of Science:

Ototoxicology
Auditory Neuroscience
Cell Biology

Context:

DDP (cisplatin) is a widely used chemotherapy agent.
Cisplatin-induced ototoxicity is a significant clinical concern, leading to hearing loss.
Understanding the cellular mechanisms of DDP ototoxicity is crucial for developing preventative strategies.

Purpose:

To investigate the dose-dependent effects of DDP on guinea pig cochlear morphology and auditory function.
To identify the specific cellular targets and the earliest signs of DDP-induced cochlear damage.

Summary:

Guinea pigs received varying doses of DDP (0, 2, or 4 mg/kg).
Auditory brainstem response (ABR) thresholds and cochlear tissues were analyzed post-administration.
DDP exposure resulted in elevated ABR thresholds and dose-dependent damage to hair cells, supporting cells, striae vascularis, and spiral ganglia, with Deiters' cells being the earliest and most severely affected.

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Impact:

This research highlights the dose-dependent ototoxicity of DDP, emphasizing the vulnerability of outer hair cells.
Findings provide critical insights into the cellular mechanisms underlying cisplatin-induced hearing loss.
The study identifies specific cochlear regions and cell types most susceptible to DDP damage, informing future therapeutic interventions.