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[Structure and function of the eosinophil leucocytes (author's transl)].

W König

    Immunitat Und Infektion
    |June 1, 1978
    PubMed
    Summary

    Eosinophilia, characterized by increased eosinophils, is linked to hypersensitivity and parasitic infections. Eosinophils combat inflammation and parasites, with their accumulation driven by complex chemotactic factors.

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    Area of Science:

    • Immunology
    • Cell Biology

    Context:

    • Eosinophils are key players in inflammatory responses, particularly in hypersensitivity reactions and parasitic infections.
    • These leukocytes counteract inflammatory mediators like histamine and slow-reacting substance of anaphylaxis (SRS-A).
    • Eosinophils also regulate mediator synthesis in mast cells and damage parasites.

    Purpose:

    • To elucidate the multifaceted role of eosinophils in various physiological and pathological conditions.
    • To explore the mechanisms driving eosinophil accumulation, including chemokinesis and chemotaxis.
    • To understand the diverse nature of eosinophilotactic factors influencing eosinophil behavior.

    Summary:

    • Eosinophilia, an increase in eosinophils, is a hallmark of hypersensitivity diseases and parasitic infections.
    • Eosinophils modulate inflammation by neutralizing mediators and exhibit direct anti-parasitic activity.
    • Their accumulation is regulated by complex chemotactic factors originating from various cells and serum components.

    Impact:

    • Provides a comprehensive overview of eosinophil functions in immunity and inflammation.
    • Highlights the complexity of eosinophil regulation, involving maturation, mediator secretion, and cellular responsiveness.
    • Establishes eosinophilia as a complex phenomenon with implications for understanding allergic and infectious diseases.

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