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Nifedipine interactions in hypertensive patients
A Salvetti1, A Magagna, B Abdel-Haq
1Cattedra di Terapia Medica Sistematica, University of Pisa, Italy.
Cardiovascular Drugs and Therapy
|August 1, 1990
Summary
Non-steroidal anti-inflammatory drugs do not affect nifedipine
Area of Science:
- Pharmacology
- Cardiovascular Medicine
Background:
- Hypertension management often requires combination therapy.
- Nifedipine is a widely used antihypertensive medication.
- Interactions between nifedipine and other drugs, including NSAIDs and diuretics, are clinically significant.
Purpose of the Study:
- To evaluate nifedipine interactions in hypertensive patients.
- To assess the impact of prostaglandin synthesis inhibition by NSAIDs on nifedipine's antihypertensive effect.
- To investigate the efficacy of combining nifedipine with thiazide diuretics.
Main Methods:
- The study reviewed existing literature on nifedipine interactions.
- Specific focus on indomethacin's effect on prostaglandin synthesis and nifedipine.
- Analysis of studies combining nifedipine with beta blockers, ACE inhibitors, clonidine, and thiazide diuretics.
Main Results:
- Indomethacin, an NSAID, did not alter the antihypertensive effect of nifedipine.
- Nifedipine is effectively combined with beta blockers, ACE inhibitors, and clonidine.
- The combination of nifedipine with thiazide diuretics, like chlorthalidone, did not show an additional antihypertensive effect in essential hypertensives.
Conclusions:
- Nifedipine's antihypertensive efficacy is not compromised by NSAID-induced prostaglandin inhibition.
- Combination therapy with nifedipine and certain antihypertensives is beneficial.
- Combining nifedipine with thiazide diuretics may not provide additive blood pressure-lowering benefits in essential hypertension.