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In vitro activity of cefixime: correlation index between MIC and disc diffusion test
A Focà1, M C Liberto, M C Berlinghieri
1Institute of Microbiology, University of Reggio Calabria, Catanzaro, Italy.
Drugs Under Experimental and Clinical Research
|January 1, 1990
Summary
Cefixime shows broad in vitro antibacterial activity, especially against enterobacteria. This study evaluated its effectiveness using MICs, MBCs, and disc diffusion tests.
Area of Science:
- Microbiology
- Pharmacology
Background:
- Cefixime is a third-generation cephalosporin antibiotic.
- Understanding its in vitro antibacterial spectrum is crucial for clinical application.
Purpose of the Study:
- To investigate the in vitro antibacterial effects of cefixime.
- To evaluate cefixime's activity against key bacterial pathogens.
- To assess the correlation between different susceptibility testing methods.
Main Methods:
- Minimum Inhibitory Concentrations (MICs) determination.
- Minimum Bactericidal Concentrations (MBCs) determination.
- Disc diffusion susceptibility testing.
- Evaluation of Enterobacteriaceae, Staphylococcus aureus, and Streptococcus pneumoniae.
Main Results:
- Cefixime demonstrated broad-spectrum in vitro activity.
- The antibiotic was particularly effective against Enterobacteriaceae.
- A correlation was observed between MIC values and disc diffusion results.
Conclusions:
- Cefixime exhibits significant in vitro antibacterial efficacy.
- Its potent activity against enterobacteria supports its use in treating related infections.
- The study validates the reliability of disc diffusion testing in conjunction with MICs.