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Increased ampicillin resistance in Haemophilus influenzae in Northern Ireland hospitals

P G Murphy1, I Craig

  • 1Department of Bacteriology, Belfast City Hospital.

Irish Journal of Medical Science
|August 1, 1990
PubMed

Insights

Ampicillin resistance in Haemophilus influenzae clinical isolates from Northern Ireland hospitals reached 15% in 1985-1986, double the national average. This resistance level remained stable by 1989, indicating a persistent public health concern.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Haemophilus influenzae is a significant cause of bacterial infections.
  • Ampicillin resistance in H. influenzae poses a treatment challenge.
  • Surveillance of antimicrobial resistance is crucial for public health.

Purpose of the Study:

  • To determine the prevalence of ampicillin resistance in clinical isolates of Haemophilus influenzae in Northern Ireland.
  • To compare resistance levels to national averages and previous findings.
  • To monitor resistance trends over time.

Main Methods:

  • Analysis of clinical isolates of Haemophilus influenzae from Northern Ireland hospitals.
  • Antimicrobial susceptibility testing for ampicillin.
  • Comparison with national data and historical reports.
  • Computerised monitoring of routine specimens.

Main Results:

  • 15% (29/193) of clinical isolates of H. influenzae were ampicillin resistant during 1985-1986.
  • This prevalence was double the national average for the same period.
  • Ampicillin resistance showed a 65% increase compared to a report three years prior.
  • Resistance levels were maintained by 1989.

Conclusions:

  • A high and sustained level of ampicillin resistance in H. influenzae was observed in Northern Ireland.
  • The findings highlight the need for ongoing surveillance and potential adjustments in treatment guidelines.
  • Further discussion on susceptibility to other antimicrobials is warranted.

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