In vivo volume-selective metabolite editing via correlated z-order

Volume-selected 1H NMR spectroscopy was combined with spectral editing to selectively detect brain metabolites. The SPACE localization sequence was used to create a voxel of zeta-magnetization which could then be edited for any scalar coupled metabolite by the use of selective excitation in the ECZOTIC sequence to generate longitudinal spin order. The sequence returns an edited signal with no intrinsic loss of magnetization. The method was applied to observe approximately 10 mM ethanol and 17 mM lactate in the brain of a dog.