[Hemodynamic changes in hepatic transplant in pigs anesthetized with isoflurane]

An anesthetic model with isofluorane is reported, with the hemodynamic abnormalities induced in 10 pigs of Landrace breed undergoing orthotopic hepatic transplant with centrifugal pump. ECG, arterial blood pressure, central venous pressure, pulmonary artery pressure and rectal temperature were monitored in all the animals. Hemodynamic parameters were measured in four periods: a) baseline; b) preanhepatic phase; c) anhepatic phase, and d) after revascularization. After a period of hemodynamic stability in preanhepatic phase, there was a reduction in cardiac output (p less than 0.01) and stroke volume (p less than 0.05) and an increase in heart rate, which were maintained during the rest of the operation. Central venous pressure, pulmonary capillary pressure and mean arterial pressure remained constant. Throughout the process there was a progressive increase in systemic vascular resistances, particularly pulmonary vascular resistance which, together with mean pulmonary arterial pressure, showed a significant increase in the last phase. During the bypass period there was a significant reduction of temperature. It was concluded that satisfactory results in experimental liver transplant are achieved with isofluorane and venous bypass with centrifugal pump.