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[Neonatal systemic candidiasis]
B Flores Antón1, M C Barrio Andrés, C de Alba Romero
1Departamento de Pediatría, Hospital 12 de Octubre, Madrid.
Abstract:
We analysed 7 cases of systemic candida sp. infection diagnosed between 1986 to 1989. Clinical presentation was of sepsis. Evolution was favorable in all, excepting two cases that died due to a candidiasic meningitis and a candidiasic aortic thrombosis, respectively. Almost all patients were treated with amphotericin B only. A newborn had signs of toxicity (thrombocytopenia). We emphasize the importance of a prompt diagnosis and treatment and the effectivity of amphotericin B for systemic candidiasis, besides of its rare toxicity in newborns.
Insights
Systemic Candida infections presented as sepsis in seven cases. Prompt diagnosis and treatment with amphotericin B were effective, though two patients died from meningitis or aortic thrombosis. Newborn toxicity was rare.
Area of Science:
- Mycology
- Infectious Diseases
- Clinical Medicine
Context:
- Analysis of seven cases of systemic Candida sp. infection.
- Diagnosis period: 1986-1989.
- Clinical presentation mimicked sepsis.
Purpose:
- To evaluate the clinical presentation, treatment, and outcomes of systemic Candida infections.
- To highlight the efficacy and toxicity of amphotericin B in treating systemic candidiasis.
Summary:
- Seven patients with systemic Candida infection were analyzed, all presenting with sepsis.
- Two cases resulted in mortality due to candidiasis-related meningitis and aortic thrombosis.
- Most patients received amphotericin B, demonstrating treatment effectiveness with rare toxicity, even in newborns.
Impact:
- Emphasizes the critical role of early diagnosis and intervention in managing systemic candidiasis.
- Confirms amphotericin B as an effective treatment for systemic Candida infections.
- Suggests a favorable safety profile for amphotericin B in neonatal cases, despite potential toxicity.