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Related Experiment Videos

[Neonatal systemic candidiasis].

B Flores Antón1, M C Barrio Andrés, C de Alba Romero

  • 1Departamento de Pediatría, Hospital 12 de Octubre, Madrid.

Anales Espanoles De Pediatria
|December 1, 1990
PubMed
Summary
This summary is machine-generated.

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Systemic Candida infections presented as sepsis in seven cases. Prompt diagnosis and treatment with amphotericin B were effective, though two patients died from meningitis or aortic thrombosis. Newborn toxicity was rare.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Medicine

Context:

  • Analysis of seven cases of systemic Candida sp. infection.
  • Diagnosis period: 1986-1989.
  • Clinical presentation mimicked sepsis.

Purpose:

  • To evaluate the clinical presentation, treatment, and outcomes of systemic Candida infections.
  • To highlight the efficacy and toxicity of amphotericin B in treating systemic candidiasis.

Summary:

  • Seven patients with systemic Candida infection were analyzed, all presenting with sepsis.
  • Two cases resulted in mortality due to candidiasis-related meningitis and aortic thrombosis.
  • Most patients received amphotericin B, demonstrating treatment effectiveness with rare toxicity, even in newborns.

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Impact:

  • Emphasizes the critical role of early diagnosis and intervention in managing systemic candidiasis.
  • Confirms amphotericin B as an effective treatment for systemic Candida infections.
  • Suggests a favorable safety profile for amphotericin B in neonatal cases, despite potential toxicity.