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[Macroprolactinemia in a child].

J Weill1, S Petit, C Stuckens

  • 1l'Unité d'Endocrinologie Pédiatrique, Hôpital A. Calmette, Lille.

Archives Francaises De Pediatrie
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

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Elevated prolactin levels in a boy with psychosocial dwarfism were due to a larger prolactin variant, a condition known as macroprolactinemia. This syndrome requires consideration when clinical signs and prolactin levels appear mismatched.

Area of Science:

  • Endocrinology
  • Pediatrics

Background:

  • Hyperprolactinemia can present with various clinical symptoms.
  • Psychosocial dwarfism is a condition characterized by growth failure due to emotional deprivation.

Observation:

  • An 11-year-old boy with psychosocial dwarfism exhibited elevated basal serum prolactin levels (41-135 ng/ml).
  • Chromatography revealed the predominant prolactin form was a larger molecular weight variant, not the typical 22 kDa form.

Findings:

  • The patient presented with macroprolactinemia, a condition where larger prolactin variants circulate.
  • Prolactin levels showed a significant increase (29-76%) after thyrotropin-releasing hormone (TRH) stimulation.
  • Bromocriptine treatment (2.5 mg/day) did not effectively lower prolactin levels.

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Implications:

  • Macroprolactinemia should be suspected in cases of discordant clinical presentation and elevated prolactin levels.
  • This finding highlights the importance of characterizing prolactin variants in diagnosing hyperprolactinemia, especially in pediatric cases.