Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evidence for nonsynaptic neuronal interaction.

D L Alkon, Y Grossman

    Journal of Neurophysiology
    |May 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Cobalt ions (Co2+) block synaptic transmission in Hermissenda, but hair cell depolarization persists. This persistent depolarization is likely due to potassium accumulation, indicating a nonsynaptic excitation mechanism.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Heterogenous Distribution of Fluorescent Phorbol Ester Signal in Living Sea Urchin Embryos.

    The Biological bulletin·2018
    Same author

    Statistical computer model analysis of the reciprocal and recurrent inhibitions of the Ia-EPSP in α-motoneurons.

    Neural computation·2012
    Same author

    PKC activator therapeutic for mild traumatic brain injury in mice.

    Neurobiology of disease·2010
    Same author

    Larval rearing, metamorphosis, growth and reproduction of the eolid nudibranch hermissenda crassicornis (eschscholtz, 1831) (gastropoda: opisthobranchia).

    The Biological bulletin·2010
    Same author

    The efficacy of physiological and pharmacological N-methyl-D-aspartate receptor block is greatly reduced under hyperbaric conditions.

    Neuroscience·2010
    Same author

    Statistical computer model analysis of the reciprocal and recurrent inhibitory postsynaptic potentials in alpha-motoneurons.

    Neural computation·2010

    Area of Science:

    • Neuroscience
    • Marine Biology
    • Cellular Physiology

    Background:

    • Synaptic interactions are crucial for sensory processing in Hermissenda.
    • Understanding the mechanisms of excitation and blockade is key to deciphering neural circuits.

    Purpose of the Study:

    • To investigate the effects of cobalt ions (Co2+) and low calcium on synaptic transmission and hair cell depolarization in Hermissenda.
    • To elucidate the underlying mechanisms of persistent hair cell depolarization.

    Main Methods:

    • Exposure of Hermissenda neural preparations to varying concentrations of cobalt ions (Co2+) and calcium (Ca2+).
    • Recording of electrical activity, including photoreceptor impulses and hair cell responses.
    • Monitoring of extracellular potassium accumulation.

    Related Experiment Videos

    Main Results:

    • Cobalt ions (Co2+) and low calcium plus cobalt ions (Co2+) eliminated synaptic interactions.
    • Depolarization of hair cells by type A photoreceptor impulses persisted after synaptic blockade.
    • Persistent depolarization correlated with potassium accumulation and was independent of membrane potential.
    • Nonsynaptic excitation of hair cells by type A photoreceptor impulses was evidenced, likely mediated by potassium accumulation.

    Conclusions:

    • Synaptic transmission in Hermissenda is highly sensitive to cobalt ions (Co2+).
    • Nonsynaptic excitation of hair cells by photoreceptor impulses occurs via potassium accumulation.
    • This study reveals a novel mechanism of neural excitation in Hermissenda.