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Polydipsia, polyuria, and hypertension associated with renin-secreting Wilms tumor
Insights
A pediatric Wilms tumor caused severe hypertension and polyuria by producing excess renin. Surgical removal of the tumor resolved these symptoms, highlighting the tumor's role in the infant's condition.
Area of Science:
- Pediatric Endocrinology
- Nephrology
- Oncology
Background:
- A 16-month-old infant presented with severe thirst, polyuria, hyponatremia, and hypertension.
- Standard treatments for polyuria (vasopressin) and hypertension were ineffective.
Abstract:
A 16-month-old black male infant had unusual thirst, polyuria, hyponatremia, and hypertension. His polyuria was unresponsive to vasopressin therapy, and his high blood pressure was not effectively controlled by antihypertensive drugs. Radiographic examinations revealed an occult Wilms tumor in the right kidney. After removal of the tumor, the signs and symptoms were relieved. The tumor had a renin activity about 280 times that of the adjacent renal cortex, and many intracytoplasmic secretory granules were found on electron microscopy. The pathogenesis of these clinical manifestations appears to be mediated through the physiologic pathways of renin-angiotensin II and renin-aldosterone.