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The evolving concept of gene therapy.

T Friedmann1

  • 1Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla 92093.

Human Gene Therapy
|January 1, 1990
PubMed
Summary

Gene therapy, using molecular techniques to correct genetic diseases, is now feasible due to advancements in DNA technology and gene transfer methods. Collaboration between scientists and medical professionals is crucial for clinical application.

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Medical Genetics

Background:

  • Human gene therapy was once considered highly improbable.
  • Scientific attitudes have shifted due to key technological and ethical developments.

Purpose of the Study:

  • To highlight the recent advancements enabling human gene therapy.
  • To advocate for interdisciplinary collaboration to advance clinical gene therapy.

Main Methods:

  • Development of recombinant DNA technology for gene cloning.
  • Advancements in gene transfer techniques for mammalian cells.
  • Maturation of scientific and ethical considerations in human experimentation.

Main Results:

  • Recombinant DNA technology allows cloning of disease-related genes.
  • Efficient gene transfer into mammalian cells is now possible.
  • Ethical considerations have evolved, addressing past experimental challenges.

Conclusions:

  • Human gene therapy is now a scientifically viable concept.
  • Interdisciplinary cooperation is essential to translate gene therapy into clinical practice.
  • The time is opportune for the scientific and medical communities to advance gene therapy applications.
Keywords:
Genetics and ReproductionHuman Genome Project

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