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Does growth hormone influence the severity of phosphopenic rickets?
T Bistritzer1, S A Chalew, A Hanukoglu
1University of Maryland School of Medicine, Baltimore.
European Journal of Pediatrics
|November 1, 1990
Summary
Phosphopenic rickets severity doesn't correlate with phosphate levels. Spontaneous growth hormone (GH) secretion may influence rachitic changes, with lower GH levels linked to milder bone disease in children.
Area of Science:
- Pediatric Endocrinology
- Bone Metabolism
- Growth Hormone Physiology
Background:
- Phosphopenic rickets is a bone disorder characterized by impaired phosphate reabsorption.
- The relationship between disease severity and serum phosphate levels in phosphopenic rickets is not well-defined.
- The potential role of growth hormone (GH) in the pathogenesis or severity of phosphopenic rickets requires investigation.
Purpose of the Study:
- To investigate the potential influence of spontaneous growth hormone (GH) secretion on the severity of rachitic changes in children with phosphopenic rickets.
- To evaluate the 24-hour integrated concentration of growth hormone (IC-GH) in relation to clinical and radiographic findings.
Main Methods:
- Studied five children diagnosed with phosphopenic rickets.
- Measured the 24-hour integrated concentration of growth hormone (IC-GH) in all participants.
- Assessed clinical and radiographic evidence of rickets severity.
Main Results:
- Two patients with severe rickets exhibited normal IC-GH levels.
- Three patients with mild rickets demonstrated low IC-GH levels.
- No direct correlation was observed between serum phosphate levels and rickets severity.
Conclusions:
- Spontaneous GH secretion may be a contributing factor influencing the severity of phosphopenic rickets.
- Lower levels of GH secretion might be associated with milder manifestations of the disease.
- Further research is warranted to elucidate the precise role of GH in phosphopenic rickets.