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Related Experiment Videos

Modification of septic processes by beta-glucan administration.

T Tsujinaka1, M Yokota, J Kambayashi

  • 1Second Department of Surgery, Osaka University Medical School, Japan.

European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes
|January 1, 1990
PubMed
Summary

Beta-(1→3)-glucan (lentinan) from Lentinus edodes mitigated sepsis effects in rabbits. Lentinan treatment prevented platelet drops and reduced organ damage markers, suggesting its therapeutic potential in sepsis.

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Area of Science:

  • Immunology
  • Pharmacology
  • Microbiology

Background:

  • Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.
  • Beta-glucans are known immunomodulators with potential therapeutic applications.
  • Lentinan, a specific beta-(1→3)-glucan from Lentinus edodes, has shown various biological activities.

Purpose of the Study:

  • To evaluate the therapeutic effect of lentinan in a clinically relevant rabbit model of sepsis.
  • To assess the impact of lentinan on key sepsis indicators and organ function markers.
  • To investigate the potential of beta-(1→3)-glucan as an adjunctive therapy for sepsis.

Main Methods:

  • A septic model was established in male rabbits by inducing a septic insult via fecal suspension injection.

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  • Lentinan (beta-(1→3)-glucan) was administered intravenously before the septic insult.
  • Parameters monitored included platelet counts, paracoagulation test, plasma bilirubin, creatinine, and endotoxin levels.

    • Main Results:

    • Lentinan treatment prevented the significant drop in platelet counts observed in untreated septic rabbits.
    • The paracoagulation test and elevations in plasma bilirubin and creatinine were less pronounced in lentinan-treated animals.
    • Plasma endotoxin levels were significantly lower in lentinan-treated septic rabbits compared to untreated controls.

    Conclusions:

    • Administration of beta-(1→3)-glucan (lentinan) modified the septic process in a rabbit model.
    • Lentinan demonstrated protective effects against sepsis-induced thrombocytopenia and organ dysfunction.
    • These findings suggest that lentinan may be a potential therapeutic agent for sepsis management.