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Decreased activity of liver coproporphyrinogen oxidase in hexachlorobenzene-induced porphyria
1Institute of Gastroenterology and Nutrition, Bulgarian Medical Academy, Sofia.
Experimental Pathology
|January 1, 1990
Abstract:
A 2.5-time decrease of hepatic coproporphyrinogen oxidase activity was established in mice fed for 8 weeks with a diet containing 0.02% hexachlorobenzene. The enzyme activity was determined by a newly developed technique measuring directly the unconverted substrate, coproporphyrinogen III, with reverse phase HPLC (high-performance liquid chromatography) after its spontaneous oxidation to coproporphyrin.