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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Related Experiment Video

Updated: Jun 9, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Association between Previous Tuberculous Infection and Cerebal Glioma.

D W Ward, M L Mattison, R Finn

British Medical Journal

|August 27, 2010

Summary

Patients with cerebral gliomas show a higher incidence of prior tuberculosis infection. This suggests a potential link between defective immunity and the development of brain tumors.

Area of Science:

Neuro-oncology
Infectious Diseases
Immunology

Background:

Cerebral gliomas are primary brain tumors with complex etiologies.
Tuberculosis (TB) is a significant global infectious disease.
Immune system dysregulation is implicated in various cancers.

Purpose of the Study:

To investigate the association between a history of tuberculosis infection and the occurrence of cerebral gliomas.
To explore the role of compromised immunity as a potential shared etiological factor.

Main Methods:

Retrospective analysis of patient medical histories.
Epidemiological comparison of glioma patients and control groups.
Assessment of previous tuberculosis infection markers.

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Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

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Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

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Main Results:

A statistically significant increase in the incidence of previous tuberculosis infection was observed in patients diagnosed with cerebral gliomas.
This finding suggests a potential correlation between prior TB exposure and glioma development.

Conclusions:

Defective immunity may serve as a common underlying factor linking tuberculosis infection and cerebral gliomas.
Further research is warranted to elucidate the precise immunological mechanisms involved.