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[Therapy of pediatric infections with cefixime]
1Fachabteilung für Kinderheilkunde und Jugendmedizin des St.-Josefs-Krankenhauses, Freiburg, Germany.
Insights
Cefixime, a new oral cephalosporin antibiotic, showed good clinical efficacy in 13 of 15 children with bacterial infections. This antibiotic was well-tolerated by all pediatric patients in the pilot study.
Area of Science:
- Pediatric infectious diseases
- Pharmacology of cephalosporins
- Bacterial respiratory tract infections
Context:
- Limited data on new oral cephalosporins in pediatric populations.
- Need for effective and well-tolerated antibiotics for common childhood infections.
- Pilot study design to assess initial efficacy and safety.
Purpose:
- To investigate the efficacy and tolerance of cefixime in children.
- To evaluate cefixime for treating bacterial respiratory tract, otitis media, and urinary tract infections.
- To establish appropriate dosage and treatment duration for pediatric use.
Summary:
- A pilot study assessed cefixime in 15 children with bacterial infections.
- Children received 4 mg/kg twice daily for 7-11 days.
- Good clinical efficacy was observed in 13 patients, with excellent tolerance in all.
Impact:
- Cefixime shows promise for treating pediatric bacterial infections.
- Supports the use of cefixime in children with sensitive pathogens.
- Provides preliminary data for further clinical trials in pediatric infectious diseases.
Abstract:
In a pilot study with a limited number of patients the efficacy and tolerance of cefixime, a new oral cephalosporin antibiotic, were investigated in 15 children with the clinical diagnosis of bacterial respiratory tract infection, otitis media or urinary tract infection. The dosage was 2 x 4 mg/kg body weight daily for a period of seven to 11 days. Clinical efficacy was good in 13 cases, and subjective tolerance was good in all cases. The results support the assumption that cefixime is suited for the treatment of children with bacterial infections of the airways and urinary tract with sensitive pathogens.