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Iron in sickle cell disease.

P K Das1, A Sarangi, M Satapathy

  • 1SCB Medical College, Cutlack.

The Journal of the Association of Physicians of India
|November 1, 1990
PubMed
Summary
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Iron deficiency anemia affects 23% of sickle cell disease patients. High ferritin levels in some cases correlate with transfusions, while others show normal or low ferritin.

Area of Science:

  • Hematology
  • Nutritional Anemias
  • Genetic Blood Disorders

Background:

  • Sickle cell disease (SCD) is a genetic blood disorder.
  • Iron deficiency anemia (IDA) is a common comorbidity.
  • Understanding iron status in SCD is crucial for management.

Purpose of the Study:

  • To investigate the prevalence and characteristics of iron deficiency anemia in patients with homozygous sickle cell disease.
  • To assess iron status, including serum ferritin levels, in patients with sickle cell disease.
  • To explore the relationship between iron status, blood transfusions, and SCD genotype.

Main Methods:

  • Cross-sectional study design.
  • Analysis of iron deficiency anemia prevalence in homozygous SCD cases.

Related Experiment Videos

  • Measurement of serum ferritin levels and correlation with transfusion history.
  • Comparison of iron status between homozygous and heterozygous SCD patients.

    • Main Results:

    • Iron deficiency anemia was detected in 23% of patients with homozygous sickle cell disease.
    • Serum ferritin levels were high in 15.4% of cases, correlating with the number of transfusions.
    • No cases of tissue haemosiderosis were observed.
    • Patients with heterozygous sickle cell disease exhibited normal or low serum ferritin levels.

    Conclusions:

    • Iron deficiency anemia is a significant issue in homozygous sickle cell disease.
    • Elevated ferritin levels in SCD are primarily linked to transfusion history rather than primary iron overload.
    • Heterozygous sickle cell disease patients generally do not present with iron overload markers.