[Immunobiological features of bacterial cells of medical biofilms]

Biofilm is a integrated multucellular organism with own cycle of development, cooperative behavior of units forming it, which coordinated by QS-system based on production of signal molecules or autoinductors and ability of bacteria to receive these signals. Presence ofbacteria attached to surface of biomedical devices and formation of bacterial biofilms in the microorganism could lead to chronic inflammation, which characterized by presence of macrophages and lymphocytes in the focus of inflammation as well as proliferation of connective tissue, accumulation of matrix proteins and stimulation ofangiogenesis. Process of biofilm formation associated with activation of QS-system of different agents including potentially dangerous bacteria plays certain role in exacerbation of gastric and duodenal ulcer diseases, Crohn's disease, myocarditis, asthma, diabetes mellitus, cardiovascular and other somatic diseases. Detachment of biofilm could lead to enter ofbac-teria in bloodsream and vascular embolism. Issues related to ability of bacteria of biofilms to modulate immune response and potential for the emerging response to influence the biofilm growth and level of expression of bacterial virulence are discussed. Modem views on mechanisms of interaction of bacteria of exopolysaccharide biofilm with host's immune response factors are reviewed. The most perspective ways to control for biofilm formation and their disruption using newly developing drugs are outlined.