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Nicorandil induced perianal ulceration
J P Tiernan1, W Baraza, W Chelham
1Department of General Surgery, Sheffield Teaching Hospitals NHS Trust, United Kingdom. jtiernan@doctors.org.uk
JNMA; Journal of the Nepal Medical Association
|August 28, 2010
Summary
Nicorandil, a cardioprotective drug for angina, can rarely cause debilitating perianal ulcers. This case report details the management of such an ulcer and reviews the literature.
Area of Science:
- Cardiology
- Gastroenterology
Background:
- Nicorandil is a potassium channel activator used for angina pectoris.
- Perianal ulceration is a rare but serious adverse effect of Nicorandil therapy.
Observation:
- A case of a patient presenting with a severe perianal ulcer attributed to Nicorandil treatment is described.
- The ulcer presented diagnostic and management challenges.
Findings:
- Successful management of the Nicorandil-induced perianal ulcer was achieved.
- Literature review highlights the rarity and clinical significance of this complication.
Implications:
- Awareness of Nicorandil-induced perianal ulcers is crucial for clinicians treating angina.
- Prompt recognition and appropriate management can mitigate patient morbidity.
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