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Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

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Related Experiment Video

Updated: Jun 9, 2026

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
06:38

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

Published on: December 19, 2025

Scottish Stroke Research Network: the first three years.

K McCormick1, P Langhorne, F E J Graham

  • 1Queen Victoria Hospital, Kirkaldy, UK.

Scottish Medical Journal
|August 28, 2010
PubMed
Summary
This summary is machine-generated.

The Scottish Stroke Research Network (SSRN) enhanced clinical trial participation by 58% in three years. While recruitment increased significantly, engaging more screened stroke patients in research remains a key challenge.

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Last Updated: Jun 9, 2026

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
06:38

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

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A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
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A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

Area of Science:

  • Neurology
  • Clinical Research
  • Public Health

Background:

  • UK research networks were established to improve clinical research.
  • Stroke was identified as a priority area for local research network development.
  • The Scottish Stroke Research Network (SSRN) is one of 11 UK stroke research networks.

Purpose of the Study:

  • To review the progress of the Scottish Stroke Research Network (SSRN) in its first three years.
  • To assess the impact of the SSRN on stroke research activity and participant recruitment in Scotland.

Main Methods:

  • The study reviewed data from 2006-2009, covering the SSRN's initial three years.
  • Data included the number of active hospital research sites, stroke research nurses, and participant recruitment figures.
  • Case study data from the CLOTs trial was used to illustrate recruitment changes.

Main Results:

  • Active hospital research sites increased from 10 to 22, involving 20 stroke research nurses.
  • Participant recruitment in stroke studies rose by 58%, from 376 to 594 annually.
  • The CLOTs trial showed an increase in annual recruitment from a median of 94 to 140 patients post-SSRN involvement.

Conclusions:

  • The SSRN demonstrated significant progress in its first three years, expanding research infrastructure and participant recruitment.
  • The network currently screens approximately 50% of Scottish stroke patients.
  • Increasing the recruitment rate of screened stroke patients into supported research studies is an ongoing challenge.