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Related Concept Videos

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...

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Related Experiment Video

Updated: Jun 9, 2026

Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
06:25

Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining

Published on: December 23, 2016

Memory T cells in Rhesus macaques.

Monica Vaccari1, Genoveffa Franchini

  • 1Animal Models and Retroviral Vaccine Section, NCI, NIH, Building 41, Room D804, Bethesda, Maryland 20892, USA.

Advances in Experimental Medicine and Biology
|August 28, 2010
PubMed
Summary

Rhesus macaques are valuable models for studying infectious diseases and immune responses, particularly in relation to Simian Immunodeficiency Virus (SIV). This review examines memory cell distribution and manipulation strategies in macaques for advancing medical research.

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Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype
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Multicolor Flow Cytometry Analyses of Cellular Immune Response in Rhesus Macaques
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Multicolor Flow Cytometry Analyses of Cellular Immune Response in Rhesus Macaques

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Last Updated: Jun 9, 2026

Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
06:25

Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining

Published on: December 23, 2016

Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype
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Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype

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Multicolor Flow Cytometry Analyses of Cellular Immune Response in Rhesus Macaques
07:11

Multicolor Flow Cytometry Analyses of Cellular Immune Response in Rhesus Macaques

Published on: April 22, 2010

Area of Science:

  • Primate research
  • Immunology
  • Genomics

Background:

  • Rhesus macaques (Macaca mulatta) share ~93% nucleotide sequence with humans.
  • Widely utilized in diverse medical research areas like drug testing, neurology, and genetics.
  • Serve as a crucial model for infectious diseases due to similar pathogen susceptibility as humans.

Purpose of the Study:

  • To review memory cell distribution in Rhesus macaque immunologic compartments.
  • To discuss strategies for manipulating memory cells to understand their trafficking and function.
  • To highlight the Rhesus macaque model's utility in aging immune system studies.

Main Methods:

  • Focus on studies involving Simian Immunodeficiency Virus (SIV) infection in macaques.
  • Analysis of reagents for studying innate and adaptive immune responses at the single-cell level.
  • Review of existing literature on memory cell distribution and manipulation.

Main Results:

  • Rhesus macaques are sensitive to pathogens causing human diseases, making them excellent models.
  • Development of reagents enables single-cell level study of immune responses in macaques.
  • Significant research exists on memory cells in SIV-infected macaques.

Conclusions:

  • The Rhesus macaque is an indispensable model for studying infectious diseases and immune responses.
  • Understanding memory cell dynamics in macaques aids in developing treatments for human diseases.
  • The model is particularly useful for research on immune system aging.