Related Experiment Videos
Intestinal schwannoma in a rhesus monkey
1Toxicology Department, Sterling Research Group, Rensselaer, NY 12144.
Journal of Comparative Pathology
|November 1, 1990
Summary
A rare intestinal schwannoma (neurilemmoma) was identified in a rhesus monkey. This benign neoplasm displayed characteristic Antoni type A and B cells with unique collagen fibrils, despite its size.
Area of Science:
- Veterinary Pathology
- Primate Oncology
- Gastrointestinal Neoplasms
Background:
- Schwannomas, also known as neurilemmomas, are nerve sheath tumors that can occur in various species.
- Intestinal neoplasms in non-human primates are relatively uncommon, making case reports valuable for comparative pathology.
Observation:
- A spontaneous intestinal schwannoma was diagnosed in an aged female rhesus monkey.
- The tumor exhibited classic Antoni type A (spindle cells with palisades) and Antoni type B (plump, vacuolated cells) patterns.
- Histological examination revealed prominent hyalinized perivascular cuffs and multifocal thromboses within vascular channels.
Findings:
- Electron microscopy confirmed the presence of long-spacing collagen fibrils (100-120 nm) in the intercellular matrix, characteristic of schwannomas.
- Despite the neoplasm's significant size and invasion beyond the muscularis externa, cytological features were consistent with a benign tumor.
- Argyrophilic fibers surrounded the spindle-shaped cells, further supporting the diagnosis.
Implications:
- This case contributes to the understanding of spontaneous gastrointestinal tumors in rhesus monkeys.
- Provides histopathological and ultrastructural data for schwannoma in non-human primates.
- Highlights the importance of thorough histopathological evaluation for accurate tumor classification and prognosis in research animals.